{"id":10,"date":"2026-09-01T14:45:04","date_gmt":"2026-09-01T14:45:04","guid":{"rendered":"https:\/\/restorativeimm.wpenginepowered.com\/?page_id=10"},"modified":"2026-09-13T16:50:18","modified_gmt":"2026-09-13T16:50:18","slug":"home","status":"publish","type":"page","link":"https:\/\/www.restorative-immunology.ac.uk\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t
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Restoring immune balance. Rebuilding health. Transforming lives.<\/strong><\/h1>\n\t\t\t\t\t

The MRC Centre of Research Excellence in Restorative Immunology is pioneering a new approach to inflammatory disease: moving beyond controlling inflammation towards restoring healthy immune function and tissue health.<\/p>\n\t\t\t\t\t\n

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Why restorative immunology?<\/strong><\/h2>\n\t\t\t\t\t

Immune-mediated inflammatory diseases can affect people throughout life and cause lasting damage to tissues and organs. Treatments have transformed care, but they mainly work by suppressing inflammation. For many people, disease returns when treatment stops.

We want to understand what it takes to restore diseased tissues to a genuinely healthy state. By identifying the cellular and molecular processes that resolve inflammation and restore immune balance, our aim is to move towards sustained, drug-free remission.<\/p>\n\t\t\n<\/div>\n

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Beyond suppression<\/h3>\n\t\t\t\t\t

Current treatments can control inflammation and reduce disease activity.<\/p>\n\t\t\n<\/div>\n

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Restore healthy function<\/h3>\n\t\t\t\t\t

Understand how to restore healthy immune function and tissue health.<\/p>\n\t\t\n<\/div>\n

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Sustain remission<\/h3>\n\t\t\t\t\t

Work towards sustained, drug-free remission.<\/p>\n\t\t\n<\/div>\n\n<\/div>\n\n<\/div>\n

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Our research<\/strong><\/h2>\n\t\t\t\t\t

Our research is organised across three connected research streams. We combine detailed information from patients and tissues with experimental models and experimental medicine studies to understand how inflammatory disease can be resolved.

The streams work as a continuous translational cycle. Observations made in patients inform laboratory and computational research, promising mechanisms can move towards experimental medicine, and findings in patients feed back into the next stage of discovery.<\/p>\n\t\t

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Data exploration<\/h3>\n\t\t\t\t\t

Build integrated multi-omic datasets to understand disease across tissues, patients and time.<\/p>\n\t\t\n<\/div>\n

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Mechanisms of tissue restoration<\/h3>\n\t\t\t\t\t

Identify the cellular and molecular mechanisms that drive tissue damage, repair and restoration.<\/p>\n\t\t\n<\/div>\n

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Experimental medicine<\/h3>\n\t\t\t\t\t

Develop and test tissue-based approaches to assess immune restoration and support experimental medicine studies.<\/p>\n\t\t\n<\/div>\n\n<\/div>\n\n<\/div>\n

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Working across inflammatory diseases<\/strong><\/h2>\n\t\t\t\t\t

Different inflammatory diseases affect different organs, but they can share biological processes that determine whether inflammation persists or resolves. By studying diseases and tissues together, we can identify mechanisms of restoration that are shared across conditions, as well as those that are specific to individual tissues.<\/p>\n\t\t

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Inflammatory arthritis<\/strong><\/h3>\n\t\t\t\t\t

Joints and synovial tissue<\/p>\n\t\t\n<\/div>\n

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Inflammatory bowel disease<\/strong><\/h3>\n\t\t\t\t\t

Gut<\/p>\n\t\t\n<\/div>\n

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Autoimmune liver disease<\/strong><\/h3>\n\t\t\t\t\t

Liver<\/p>\n\t\t\n<\/div>\n

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Sj\u00f6gren\u2019s disease<\/strong>

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Salivary glands<\/p>\n\t\t\n<\/div>\n\n<\/div>\n\n<\/div>\n

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How we work<\/strong><\/h2>\n\t\t\t\t\t

Restorative immunology depends on more than scientific discovery alone. We are building a collaborative research environment that brings together patients and the public, researchers at different career stages, academic and clinical partners, and organisations beyond academia<\/p>\n\t\t

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Working with patients and the public<\/strong><\/h2>\n\t\t\t\t\t

People affected by inflammatory disease will help shape the Centre\u2019s research, from developing studies and reviewing communications to contributing to appropriate boards and working groups<\/p>\n\t\t\n<\/div>\n

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Developing the next generation<\/strong><\/h2>\n\t\t\t\t\t

We will invest in doctoral students, early- and mid-career researchers through interdisciplinary training, mentoring and opportunities to develop new skills, collaborations and leadership experience<\/p>\n\t\t\n<\/div>\n

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Working with partners<\/strong><\/h2>\n\t\t\t\t\t

We will work with industry, charities, healthcare organisations and other partners to bring together therapeutic assets, technology, data and specialist expertise and help translate discoveries towards patient benefit<\/p>\n\t\t\n<\/div>\n

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Building an inclusive research culture<\/strong><\/h2>\n\t\t\t\t\t

We are building a Centre-wide research culture that supports collaboration across disciplines and institutions, values different career stages and professional backgrounds, and creates opportunities for people to contribute, develop and lead<\/p>\n\t\t\n<\/div>\n\n<\/div>\n\n<\/div>\n

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One Centre, working across institutions<\/strong><\/h2>\n\t\t\t\t\t

The Centre brings together clinical teams and scientists across multiple disciplines and institutions, alongside industry, charities, healthcare providers and patient groups. Together, they provide expertise and infrastructure spanning data science, tissue immunology, experimental medicine and the development of new therapies.

Working across institutional and disciplinary boundaries allows us to connect discovery science with clinical research and accelerate the translation of promising findings towards patient benefit.<\/p>\n\t\t

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People and leadership<\/strong><\/h2>\n\t\t\t\t\t

The Centre is led by an interdisciplinary team of researchers, clinicians and research professionals working across our partner institutions. Our leadership structure connects scientific direction with the operational, training, research culture, data governance and partnership activity needed to deliver the Centre\u2019s ambitions.<\/p>\n\t\t\n<\/div>\n

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Latest from the Centre<\/strong><\/h2>\n\t\t\t\t\t

News, events, opportunities and updates from across the Centre.<\/p>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t View all news \u2192<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n
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Stay connected<\/strong><\/h2>\n\t\t\t\t\t

Follow the Centre for research updates, opportunities, events and news from across our community.<\/p>\n\t\t

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Discover the MRC Centre of Research Excellence in Restorative Immunology and our ambition to restore healthy immune function and tissue health in immune-mediated inflammatory disease.<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nRestorative Immunology | MRC Centre of Research Excellence<\/title>\n<meta name=\"description\" content=\"Discover the MRC Centre of Research Excellence in Restorative Immunology and our research to restore healthy immune function and tissue health\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.restorative-immunology.ac.uk\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta 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